KMID : 1134820200490060631
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Journal of the Korean Society of Food Science and Nutrition 2020 Volume.49 No. 6 p.631 ~ p.637
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Inhibitory Effects of Aralia elata Sprout Hot-Water Extract on Adipocyte Differentiation and Triglyceride Synthesis in 3T3-L1 Cells
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Choi Ra-Yeong
Lee Hae-In Yun Kyeong-Won Ham Ju-Ri Lee Mi-Kyung
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Abstract
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Aralia elata Seem. is distributed widely in Korea, China, and Japan, and its sprouts (dureupsoon) are a popular edible vegetable in spring. This study evaluated the anti-obesity activity of the hot-water extract (ASE) of Aralia elata sprout in 3T3-L1 cells and its underlying mechanism. ASE did not affect the 3T3-L1 cell viability at 100, 200, and 400 ¥ìg/mL. The ASE treatment inhibited adipocytes differentiation significantly in a dose-dependent manner, and it dose-independently reduced the intracellular triglyceride levels. ASE down-regulated adipogenic gene (peroxisome proliferator-activated receptor ¥ã) and lipogenic gene (sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase 1, diacylglycerol O-acyltransferase 2) significantly compared to the vehicle control. These results suggest that ASE could be a promising functional material for anti-obesity.
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KEYWORD
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3T3-L1, Aralia elata sprout, adipogenesis, dureupsoon, lipogenesis
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